Search results for "Cerebral metabolism"
showing 3 items of 3 documents
The isolated perfused rat brain as a model for studying drugs acting on the CNS
1974
An isolated perfused brain preparation is regarded as offering some important advantages over intact animals or tissue slices for studying drug effects on the CNS. The rat is by far the most suitable laboratory animal for this technique because of low cost, ease of preparation and extensive literature available for comparative purposes. In this paper various preparation techniques and perfusion systems for an isolated rat brain are reported. Investigations are presented proving the viability of the isolated perfused rat brain for more than seven hours and its suitability for studies on cerebral metabolism. Until now this preparation has been successfully used for pharmacological investigati…
The phenylketonuria mouse model: a meeting review
2002
a Department of Biological Sciences, Wichita State University, Wichita, Kansas, USA b OASI Istituto per la ricerca sul ritardo mentale e l’involuzione cerebrale, Troina, Sicily, Italy c Department of Biopathology and Biomedical Methodology, University of Palermo, Palermo, Sicily, Italy d Department of Psychology, University of Rome, and Fondazione Santa Lucia IRCCS, Rome, Italy e McGill University—Montreal Children’s Hospital Research Institute, Montreal, Que., Canada f Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD, USA
Cerebral metabolism after transient ischemic attack. A 1H MR spectroscopy study
1999
International audience; Abstract: Metabolic changes induced by cerebral infarction or by stenosis and occlusion of the internal carotid artery have been previously described in 1H Magnetic Resonance Spectroscopy (1H MRS). These changes are essentially characterized by decreased N-acetyl-aspartate (NAA) and increased lactate concentration. Little is known about the metabolic changes observed in the three days following a transient ischemic attack (TIA) in the absence of stenosis or occlusion of the internal carotid artery, and without visible infarction on Magnetic Resonance imaging (MRI). We studied five patients with a TIA lasting between 30 min and 3 h, affecting the sensory and motor fun…